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Nitric Oxide -The Secret Ingredient to Hardness & Lasting Longer

Importance of nitric oxide for male sexual health:

Nitric oxide is an important chemical compound which plays an important role in male sexual function.  Increased levels of nitric oxide improve circulation, lead to increased frequency of erections and been shown to improve staying power harder and firmer erections. Conversely, lower levels of nitric oxide can lead to soft erections and premature ejaculation.

How does nitric oxide work?

It is nitric oxide is responsible for signally the smooth muscle of the penis to relax. This leads to vasodilation (blood vessel dilation) and increased blood flow resulting in harder, firmer and more frequent erections.

Popular prescription ED medications such as Sildenafil (Viagra), Tadalafil (Cialis) and Vardenafil (Levitra) all use this same mechanism to function. These medications are typically referred to as PDE-5 inhibitors.

Recently, PDE-5 inhibitors have also been found to play a role in premature ejaculation [1]. Following a study at the Mansoura Facility of Medicine, researchers stated that possible reasons for prolonging ejaculation is that PDE-5 inhibitors modulate the response of the vas deferens, seminal vesicles, prostate and urethra [2].


How to increase nitric oxide levels in the body?

There are two ways to boost nitric oxide levels:

1. Introduce a substance that the body uses to produce nitric oxide. A very popular non-essential amino acid is Arginine. Arginine can be found in many foods and are also present in many popular supplements.

2. Prevent the body from destroying nitric oxide. This is the same method popular prescription ED drugs. They phosphodiesterase-5 (PDE5) inhibitors which block the PDE-5 enzyme resulting in helping to smooth the muscles of the penis to relax and increase blood flow.


Natural Alternative for Nitric Oxide Boost:

There are also herbs which have been shown to  function very similarly to the pharmaceutical drugs. Most notably, Horny Goat Weed (Epimedium) which has been shown to inhibit the PDE-5 enzyme [3]. Panax Ginseng has also been shown to be increase nitric oxide levels [4].



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1. Chen J, Keren-Paz G, Bar-Yosef Y, Matzkin H. The role of phosphodiesterase type 5 inhibitors in the management of premature ejaculation: a critical analysis of basic science and clinical data. 2007. Department of Urology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

2. Abdel-Hamid IA. Phosphodiesterase 5 inhibitors in rapid ejaculation: potential use and possible mechanisms of action. Department of Andrology, Mansoura Faculty of Medicine, Mansoura, Egypt. 2004.

3. Chen KK, Chiu JH. Effect of Epimedium brevicornum Maxim extract on elicitation of penile erection in the rat. Urology. 2006;67:631-5. PMID 16527595

4. Murphy LL, Lee TJ. Ginseng, Sex Behavior, and Nitric Oxide. May 2002.

5. Andrew PJ, Mayer B. Enzymatic function of nitric oxide synthases. 1999. Institut f¼r Pharmakologie und Toxikologie, Karl-Franzens-Universitit Graz, Austria.

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